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Complement component C3 and C5b-9 deposition on hypoxia reperfused endothelial cells by non-HLA antibodies against RhoGDI2: A player involved in graft failure?

HLA - 1 Feb 2023

Kardol-Hoefnagel Tineke, Michielsen Laura A, Ehlers Anna M, van Zuilen Arjan D, Luijk Bart, Otten Henny G

Abstract excerpt

Antibodies against Rho GDP-dissociation inhibitor 2 (RhoGDI2) are associated with inferior graft survival in transplant patients receiving a kidney from deceased donors. Although this suggests that these antibodies contribute to graft injury because of ischemia, it remains unknown whether they are also pathogenically involved in the process of graft loss. To study this, we firstly analyzed the IgG subclass...

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Identifiers

PMID: 36266772
DOI: 10.1111/tan.14858
PMCID: PMC10091817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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