Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Relation between cytochrome P450 2D6 and lung cancer susceptibility caused by smoking].

Wei sheng yan jiu = Journal of hygiene research - 1 Jan 2007

Yan Zhen, Wu Yongjun, Wu Yiming

Abstract excerpt

Cytochrome P450 2D6(CYP2D6) is one of the prominent phase I metabolizing enzymes in hepatic tissue, and is responsible for metabolically activating the tobacco-specific nitrosamine such as NNK and nicotinamide to highly reactive metabolites, so it may play a role in lung cancer. The study of its biological characters, structure function and the relationship beween CYP2D6 genetic polymorphisms and lung cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP2D6
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Niacinamide

Share to Nitrosamines

Share to Polymorphism, Genetic

Share to Smoking

Source

Identifiers

PMID: 17424863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Relation between cytochrome P450 2D6 and lung cancer susceptibility caused by smoking].PMID 17424863Read ↗

[Researches on the polymorphism of cytochrome P450 2A6].Semantic proximity Read ↗

[Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to lung cancer--relevance to smoking].Semantic proximity Read ↗

Association between CYP2A6 genetic polymorphisms and lung cancer: a meta-analysis of case-control studies.Semantic proximity Read ↗

[CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility].Semantic proximity Read ↗

[The relationship between genetic polymorphism of metabolizing enzymes and the genetic susceptibility to lung cancer].Semantic proximity Read ↗

[CYP2D6*10 polymorphisms and lung cancer susceptibility].Semantic proximity Read ↗

CYP2D6 T188C variant is associated with lung cancer risk in the Chinese population.Semantic proximity Read ↗

[Role of cytochrome P450 2A6 polymorphism in nicotine metabolism and tobacco-dependent behaviour].Semantic proximity Read ↗

[Combined effects of genetic polymorphisms in cytochrome P450s and GSTM1 on lung cancer susceptibility].Semantic proximity Read ↗

[Individual predisposition to lung neoplasm--the role of genes involved in metabolism of carcinogens].Semantic proximity Read ↗

Polymorphisms of the GSTM1 and CYP2D6 genes associated with susceptibility to lung cancer in Chinese.Semantic proximity Read ↗

Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.