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Article

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.

Nature structural & molecular biology - 1 Jan 2013

Otomo Chinatsu, Metlagel Zoltan, Takaesu Giichi, Otomo Takanori

Abstract excerpt

The autophagy factor ATG12~ATG5 conjugate exhibits E3 ligase-like activity which facilitates the lipidation of members of the LC3 family. The crystal structure of the human ATG12~ATG5 conjugate bound to the N-terminal region of ATG16L1, the factor that recruits the conjugate to autophagosomal membranes, reveals an integrated architecture in which ATG12 docks onto ATG5 through conserved residues. ATG12 and ATG5...

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Source

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Identifiers

PMID: 23202584
DOI: 10.1038/nsmb.2431
PMCID: PMC3540207

Genes

ATG12
ATG5
ATG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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