Article
Structural basis of Atg8 activation by a homodimeric E1, Atg7.
Molecular cell - 4 Nov 2011
Noda Nobuo N, Satoo Kenji, Fujioka Yuko, Kumeta Hiroyuki, Ogura Kenji, Nakatogawa Hitoshi, Ohsumi Yoshinori, Inagaki Fuyuhiko
Abstract excerpt
E1 enzymes activate ubiquitin-like proteins and transfer them to cognate E2 enzymes. Atg7, a noncanonical E1, activates two ubiquitin-like proteins, Atg8 and Atg12, and plays a crucial role in autophagy. Here, we report crystal structures of full-length Atg7 and its C-terminal domain bound to Atg8 and MgATP, as well as a solution structure of Atg8 bound to the extreme C-terminal domain (ECTD) of Atg7. The unique...
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