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Article

Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.

Molecular cell - 4 Nov 2011

Taherbhoy Asad M, Tait Stephen W, Kaiser Stephen E, Williams Allison H, Deng Alan, Nourse Amanda, Hammel Michal, Kurinov Igor, Rock Charles O, Green Douglas R, Schulman Brenda A

Abstract excerpt

Atg7 is a noncanonical, homodimeric E1 enzyme that interacts with the noncanonical E2 enzyme, Atg3, to mediate conjugation of the ubiquitin-like protein (UBL) Atg8 during autophagy. Here we report that the unique N-terminal domain of Atg7 (Atg7(NTD)) recruits a unique "flexible region" from Atg3 (Atg3(FR)). The structure of an Atg7(NTD)-Atg3(FR) complex reveals hydrophobic residues from Atg3 engaging a conserved...

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Identifiers

PMID: 22055190
DOI: 10.1016/j.molcel.2011.08.034
PMCID: PMC3277881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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