Article
alpha1,3-Galactosyltransferase-gene knockout in cattle using a single targeting vector with loxP sequences and cre-expressing adenovirus.
Transplantation - 15 Mar 2006
Sendai Yutaka, Sawada Tokihiko, Urakawa Manami, Shinkai Yoichi, Kubota Keiichi, Hoshi Hiroyoshi, Aoyagi Yoshito
Abstract excerpt
BACKGROUND: Gene targeting in large animals has the potential to be useful in medicine as well as in agriculture. Previously, we reported the first successful targeting of the bovine alpha1,3-galactosyltransferase (alpha1,3GT) gene and establishment of a heterozygous knockout cell line. In this report, we generated both heterozygous and homozygous knockout bovine cell lines, and alpha1,3GT-gene knockout cattle....
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