Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.

Diabetes - 1 Mar 2013

Ng Maggie C Y, Saxena Richa, Li Jiang, Palmer Nicholette D, Dimitrov Latchezar, Xu Jianzhao, Rasmussen-Torvik Laura J, Zmuda Joseph M, Siscovick David S, Patel Sanjay R, Crook Errol D, Sims Mario, Chen Yii-Der I, Bertoni Alain G, Li Mingyao, Grant Struan F A, Dupuis Josée, Meigs James B, Psaty Bruce M, Pankow James S, Langefeld Carl D, Freedman Barry I, Rotter Jerome I, Wilson James G, Bowden Donald W

Abstract excerpt

Type 2 diabetes (T2D) disproportionally affects African Americans (AfA) but, to date, genetic variants identified from genome-wide association studies (GWAS) are primarily from European and Asian populations. We examined the single nucleotide polymorphism (SNP) and locus transferability of 40 reported T2D loci in six AfA GWAS consisting of 2,806 T2D case subjects with or without end-stage renal disease and 4,265...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Cohort Studies

Share to Diabetes Mellitus, Type 2

Share to Genetic Loci

Share to Genome-Wide Association Study

Share to Transcription Factor 7-Like 2 Protein

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 23193183
DOI: 10.2337/db12-0266
PMCID: PMC3581206

Genes

KCNQ1
KLF14
ADCY5
CDKAL1
GCKR
HMGA2
JAZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.PMID 23193183Read ↗

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.Semantic proximity Read ↗

Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans.Semantic proximity Read ↗

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.Semantic proximity Read ↗

Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans.Semantic proximity Read ↗

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetesSemantic proximity Read ↗

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.Semantic proximity Read ↗

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.Semantic proximity Read ↗

A comparison of type 2 diabetes risk allele load between African Americans and European Americans.Semantic proximity Read ↗

Five linkage regions each harbor multiple type 2 diabetes genes in the African American subset of the GENNID Study.Semantic proximity Read ↗

A comprehensive reanalysis of publicly available GWAS datasets reveals an X chromosome rare regulatory variant associated with high risk for type 2 diabetesSemantic proximity Read ↗

A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.Semantic proximity Read ↗

Variant level heritability estimates of type 2 diabetes in African Americans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.