Article
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
PLoS genetics - 1 Aug 2014
Ng Maggie C Y, Shriner Daniel, Chen Brian H, Li Jiang, Chen Wei-Min, Guo Xiuqing, Liu Jiankang, Bielinski Suzette J, Yanek Lisa R, Nalls Michael A, Comeau Mary E, Rasmussen-Torvik Laura J, Jensen Richard A, Evans Daniel S, Sun Yan V, An Ping, Patel Sanjay R, Lu Yingchang, Long Jirong, Armstrong Loren L, Wagenknecht Lynne, Yang Lingyao, Snively Beverly M, Palmer Nicholette D, Mudgal Poorva, Langefeld Carl D, Keene Keith L, Freedman Barry I, Mychaleckyj Josyf C, Nayak Uma, Raffel Leslie J, Goodarzi Mark O, Chen Y-D Ida, Taylor Herman A, Correa Adolfo, Sims Mario, Couper David, Pankow James S, Boerwinkle Eric, Adeyemo Adebowale, Doumatey Ayo, Chen Guanjie, Mathias Rasika A, Vaidya Dhananjay, Singleton Andrew B, Zonderman Alan B, Igo Robert P, Sedor John R, Kabagambe Edmond K, Siscovick David S, McKnight Barbara, Rice Kenneth, Liu Yongmei, Hsueh Wen-Chi, Zhao Wei, Bielak Lawrence F, Kraja Aldi, Province Michael A, Bottinger Erwin P, Gottesman Omri, Cai Qiuyin, Zheng Wei, Blot William J, Lowe William L, Pacheco Jennifer A, Crawford Dana C, Grundberg Elin, Rich Stephen S, Hayes M Geoffrey, Shu Xiao-Ou, Loos Ruth J F, Borecki Ingrid B, Peyser Patricia A, Cummings Steven R, Psaty Bruce M, Fornage Myriam, Iyengar Sudha K, Evans Michele K, Becker Diane M, Kao W H Linda, Wilson James G, Rotter Jerome I, Sale Michèle M, Liu Simin, Rotimi Charles N, Bowden Donald W
Abstract excerpt
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in...
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