Article
On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans.
The Journal of biological chemistry - 25 Mar 1990
Ragg H, Ulshöfer T, Gerewitz J
Abstract excerpt
Human leuserpin-2 (hLS2) cDNA variants generated by site-directed mutagenesis were expressed in a transient COS cell system. Functional analysis of the mutants revealed two regions in the NH2-terminal half of hLS2 which are essential for glycosaminoglycan-enhanced thrombin inhibition by hLS2. One...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Line
- Chromosome Deletion
- Dermatan Sulfate
- Genetic Variation
- Glycosaminoglycans
- Heparin
- Heparin Cofactor II
- Humans
- Kinetics
- Macromolecular Substances
- Models, Structural
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Thrombin