Article
Glycosaminoglycan-mediated leuserpin-2/thrombin interaction. Structure-function relationships.
The Journal of biological chemistry - 25 Dec 1990
Ragg H, Ulshöfer T, Gerewitz J
Abstract excerpt
Two recently identified structural elements important for glycosaminoglycan-mediated activation of human leuserpin-2 (hLS2) were investigated in detail by functional analysis of variants secreted by transiently transfected COS cells. Highly specific requirements with respect to the nature of the...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Genetic Variation
- Glycosaminoglycans
- Heparin
- Heparin Cofactor II
- Humans
- Kinetics
- Macromolecular Substances
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Thrombin
- Transfection