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Article

Genetic and epigenetic mechanisms collaborate to control SERPINA3 expression and its association with placental diseases.

Human molecular genetics - 1 May 2012

Chelbi Sonia T, Wilson Melissa L, Veillard Anne-Clémence, Ingles Sue A, Zhang Jim, Mondon Françoise, Gascoin-Lachambre Géraldine, Doridot Ludivine, Mignot Thérèse-Marie, Rebourcet Régis, Carbonne Bruno, Concordet Jean-Paul, Barbaux Sandrine, Vaiman Daniel

Abstract excerpt

SERPINA3 (Serpin peptidase inhibitor clade A member 3), also known as a1-antichymotrypsin, is a serine protease inhibitor involved in a wide range of biological processes. Recently, it has been shown to be up-regulated in human placental diseases in association with a hypomethylation of the 5' region of the gene. In the present study, we show that the promoter of SERPINA3 is transcriptionally activated by three...

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Source

Identifiers

PMID: 22246292
DOI: 10.1093/hmg/dds006

Genes

SERPINA3
MZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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