Article
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite.
Blood - 15 Oct 2007
Bayele Henry K, Peyssonnaux Carole, Giatromanolaki Alexandra, Arrais-Silva Wagner W, Mohamed Hiba S, Collins Helen, Giorgio Selma, Koukourakis Michael, Johnson Randall S, Blackwell Jenefer M, Nizet Victor, Srai Surjit Kaila S
Abstract excerpt
The Ity/Lsh/Bcg locus encodes the macrophage protein Slc11a1/Nramp1, which protects inbred mice against infection by diverse intracellular pathogens including Leishmania, Mycobacterium, and Salmonella. Human susceptibility to infectious and inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and tuberculosis, shows allelic association with a highly polymorphic regulatory,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.