Article
Full-length DQ beta cDNA sequences of HLA-DR2/DQw1 subtypes: genetic interactions between two DQ beta loci generate human class II HLA diversity.
Human immunology - 1 Apr 1990
Wu S K, Lu D, Madden M, Liu C P, Miyokawa N, Bach F H, Saunders T L
Abstract excerpt
Two-dimensional gel electrophoresis of DQ molecules from three different Dw subtypes (Dw2, Dw12, and Dw21/FJO) of the HLA-DR2/DQw1 haplotype reveals that one alpha beta heterodimer of DQ molecule is expressed by each subtype and the DQ beta chain is electrophoretically variable among the three DR...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Cell Line
- Cloning, Molecular
- Electrophoresis, Gel, Two-Dimensional
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR2 Antigen
- Humans
- Molecular Sequence Data
- Polymorphism, Genetic
- Sequence Homology, Nucleic Acid