Article
Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR specificity.
Nature - 1 Jan 2000
Gorski J, Mach B
Abstract excerpt
The polymorphic HLA-DR beta-chains are encoded within the human major histocompatibility complex (MHC) by multiple loci resulting from gene duplications. Certain DR haplotypes can be grouped into families based on shared structural factors. We have studied the molecular basis of HLA-DR polymorphism within such a group which includes the haplotypes DR3, DR5 and DRw6. Molecular mapping of the DR beta-chain region...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- Gene Conversion
- HLA-DR Antigens
- Haploidy
- Histocompatibility Antigens Class II
- Humans
- Polymorphism, Genetic