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Article

Inhibition of PbGP43 expression may suggest that gp43 is a virulence factor in Paracoccidioides brasiliensis.

PloS one - 1 Jan 2013

Torres Isaura, Hernandez Orville, Tamayo Diana, Muñoz Jose F, Leitão Natanael P, García Ana M, Restrepo Angela, Puccia Rosana, McEwen Juan G

Abstract excerpt

Glycoprotein gp43 is an immunodominant diagnostic antigen for paracoccidioidomycosis caused by Paracoccidioides brasiliensis. It is abundantly secreted in isolates such as Pb339. It is structurally related to beta-1,3-exoglucanases, however inactive. Its function in fungal biology is unknown, but it elicits humoral, innate and protective cellular immune responses; it binds to extracellular matrix-associated...

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PMID: 23874627
DOI: 10.1371/journal.pone.0068434
PMCID: PMC3708949

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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