Article
Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration.
Investigative ophthalmology & visual science - 1 Jan 2008
Despriet Dominiek D G, Bergen Arthur A B, Merriam Joanna E, Zernant Jana, Barile Gaetano R, Smith R Theodore, Barbazetto Irene A, van Soest Simone, Bakker Arne, de Jong Paulus T V M, Allikmets Rando, Klaver Caroline C W
Abstract excerpt
PURPOSE: To determine whether variants in the candidate genes TLR4, CCL2, and CCR2 are associated with age-related macular degeneration (AMD). METHODS: This study was performed in two independent Caucasian populations that included 357 cases and 173 controls from the Netherlands and 368 cases and 368 controls from the United States. Exon 4 of the TLR4 gene and the promoter, all exons, and flanking intronic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.