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Article

Individual variation in levels of haptoglobin-related protein in children from Gabon.

PloS one - 1 Jan 2012

Imrie Heather J, Fowkes Freya J I, Migot-Nabias Florence, Luty Adrian J F, Deloron Philippe, Hajduk Stephen L, Day Karen P

Abstract excerpt

BACKGROUND: Haptoglobin related protein (Hpr) is a key component of trypanosome lytic factors (TLF), a subset of high-density lipoproteins (HDL) that form the first line of human defence against African trypanosomes. Hpr, like haptoglobin (Hp) can bind to hemoglobin (Hb) and it is the Hpr-Hb complexes which bind to these parasites allowing uptake of TLF. This unique form of innate immunity is primate-specific. To...

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Identifiers

PMID: 23185445
DOI: 10.1371/journal.pone.0049816
PMCID: PMC3502254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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