Article
Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection.
PloS one - 11 Apr 2007
Cox Sharon E, Doherty Conor, Atkinson Sarah H, Nweneka Chidi V, Fulford Anthony J C, Ghattas Hala, Rockett Kirk A, Kwiatkowski Dominic P, Prentice Andrew M
Abstract excerpt
BACKGROUND: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded by the co-dominant alleles Hp1 and Hp2, have been variously associated with several infectious diseases, including malaria...
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