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Article

Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype.

PLoS medicine - 1 May 2006

Atkinson Sarah H, Rockett Kirk, Sirugo Giorgio, Bejon Philip A, Fulford Anthony, O'Connell Maria A, Bailey Robin, Kwiatkowski Dominic P, Prentice Andrew M

Abstract excerpt

BACKGROUND: Anaemia is a major cause of morbidity and mortality for children in Africa. The plasma protein haptoglobin (Hp) binds avidly to free haemoglobin released following malaria-induced haemolysis. Haptoglobin polymorphisms result in proteins with altered haemoglobin-binding capacity and different antioxidant, iron-recycling, and immune functions. Previous studies examined the importance of haptoglobin...

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Identifiers

PMID: 16637741
DOI: 10.1371/journal.pmed.0030172
PMCID: PMC1450017

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Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype.PMID 16637741Read ↗

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