Article
Haptoglobin levels are associated with haptoglobin genotype and alpha+ -Thalassemia in a malaria-endemic area.
The American journal of tropical medicine and hygiene - 1 Jun 2006
Imrie Heather, Fowkes Freya J I, Michon Pascal, Tavul Livingstone, Hume Jennifer C C, Piper Karen P, Reeder John C, Day Karen P
Abstract excerpt
Haptoglobin (Hp) is an acute phase protein that removes free hemoglobin (Hb) released during hemolysis. Hp has also been shown to be toxic for malaria parasites. alpha(+)-Thalassemia is a hemoglobinopathy that results in subclinical hemolytic anemia. alpha(+)-Thassemia homozygosity confers protection against severe malarial disease by an as yet unidentified mechanism. Hp levels were measured in a serial...
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