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Article

Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery.

PloS one - 1 Jan 2012

Valette Marion, Poitou Christine, Le Beyec Johanne, Bouillot Jean-Luc, Clement Karine, Czernichow Sébastien

Abstract excerpt

Bariatric surgery is the most effective long term weight-loss therapy for severe and morbidly obese patients. Melanocortin-4 Receptor (MC4R) mutations, the most frequent known cause of monogenic obesity, affect the regulation of energy homeostasis. The impact of such mutations on weight loss after bariatric surgery is still debated.The objective is to determine the impact of MC4R status on weight loss in obese...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptor, Melanocortin, Type 4

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Identifiers

PMID: 23185251
DOI: 10.1371/journal.pone.0048221
PMCID: PMC3504045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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