Article
Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions.
Genes - 1 Dec 2022
Salazar-Valencia Itzel G, Villamil-Ramírez Hugo, Barajas-Olmos Francisco, Guevara-Cruz Martha, Macias-Kauffer Luis R, García-Ortiz Humberto, Hernández-Vergara Omar, Díaz de Sandy-Galán David Alberto, León-Mimila Paola, Centeno-Cruz Federico, González-Salazar Luis E, Guizar-Heredia Rocío, Pichardo-Ontiveros Edgar, Jacobo-Albavera Leonor, Posadas-Sánchez Rosalinda, Vargas-Alarcón Gilberto, Velazquez-Cruz Rafael, Gutiérrez-Aguilar Ruth, Zerrweck Carlos, Rocha-González Héctor Isaac, Reyes-García Juan Gerardo, Carrasco-Portugal Miriam Del C, Flores-Murrieta Francisco Javier, Tovar Armando R, Orozco Lorena, Villarreal-Molina Teresa, Canizales-Quinteros Samuel
Abstract excerpt
The loss of function melanocortin 4-receptor (MC4R) Ile269Asn mutation has been proposed as one of the most important genetic contributors to obesity in the Mexican population. However, whether patients bearing this mutation respond differently to weight loss treatments is unknown. We tested the association of this mutation with obesity in 1683 Mexican adults, and compared the response of mutation carriers and...
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