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Article

Essential role of Kir5.1 channels in renal salt handling and blood pressure control.

JCI insight - 21 Sept 2017

Palygin Oleg, Levchenko Vladislav, Ilatovskaya Daria V, Pavlov Tengis S, Pochynyuk Oleh M, Jacob Howard J, Geurts Aron M, Hodges Matthew R, Staruschenko Alexander

Abstract excerpt

Supplementing diets with high potassium helps reduce hypertension in humans. Inwardly rectifying K+ channels Kir4.1 (Kcnj10) and Kir5.1 (Kcnj16) are highly expressed in the basolateral membrane of distal renal tubules and contribute to Na+ reabsorption and K+ secretion through the direct control of transepithelial voltage. To define the importance of Kir5.1 in blood pressure control under conditions of...

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Source

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Identifiers

PMID: 28931751
DOI: 10.1172/jci.insight.92331
PMCID: PMC5621918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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