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Article

Ligand binding to the AMP-activated protein kinase active site mediates protection of the activation loop from dephosphorylation.

The Journal of biological chemistry - 4 Jan 2013

Chandrashekarappa Dakshayini G, McCartney Rhonda R, Schmidt Martin C

Abstract excerpt

The AMP-activated protein kinase (AMPK) is a conserved signaling molecule in a pathway that maintains adenosine triphosphate homeostasis. Recent studies have suggested that low energy adenylate ligands bound to one or more sites in the γ subunit of AMPK promote the formation of an active, phosphatase-resistant conformation. We propose an alternative model in which the kinase domain association with the...

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Identifiers

PMID: 23184934
DOI: 10.1074/jbc.M112.422659
PMCID: PMC3537075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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