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Article

MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome children.

Disease markers - 1 Jan 2008

Meguid Nagwa A, Dardir Ahmed A, Khass Mohamed, Hossieny Lamia El, Ezzat Afaf, El Awady Mostafa K

Abstract excerpt

Recent reports linking Down syndrome (DS) to maternal polymorphisms at the methylenetetrahydrofolate reductase (MTHFR) gene locus have generated great interest among investigators in the field. The present study aimed at evaluation of MTHFR 677C/T and 1298A/C polymorphisms in the MTHFR gene as maternal risk factors for DS. Forty two mothers of proven DS outcomes and forty eight control mothers with normal...

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Source

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Identifiers

PMID: 18057532
DOI: 10.1155/2008/214027
PMCID: PMC3850629

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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