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Article

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a meta-analysis.

European journal of obstetrics, gynecology, and reproductive biology - 1 Apr 2013

Wu Xiaoming, Wang Xiaohuan, Chan Ying, Jia Shuting, Luo Ying, Tang Wenru

Abstract excerpt

OBJECTIVES: MTHFR C677T and A1298C have been associated with the risk of having an infant with Down syndrome (DS), but results were conflicting. We performed this meta-analysis to derive a more precise estimation of the association between maternal MTHFR polymorphisms and DS. STUDY DESIGN: An ele...

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Source

Identifiers

PMID: 23295071
DOI: 10.1016/j.ejogrb.2012.11.022

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23295071-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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