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Article

Genetic polymorphisms involved in folate metabolism and maternal risk for down syndrome: a meta-analysis.

Disease markers - 1 Jan 2014

Balduino Victorino Daniella, de Godoy Moacir Fernandes, Goloni-Bertollo Eny Maria, Pavarino Érika Cristina

Abstract excerpt

Inconclusive results of the association between genetic polymorphisms involved in folate metabolism and maternal risk for Down syndrome (DS) have been reported. Therefore, this meta-analysis was conducted. We searched electronic databases through May, 2014, for eligible studies. Pooled odds ratios with 95% confidence intervals were used to assess the strength of the association, which was estimated by fixed or...

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Source

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Identifiers

PMID: 25544792
DOI: 10.1155/2014/517504
PMCID: PMC4269293

Genes

MTHFD1
MTRR
CBS
MTR

Variants

rs1801394
rs1805087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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