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Article

Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders.

PloS one - 1 Jan 2015

Oliveira José, Etain Bruno, Lajnef Mohamed, Hamdani Nora, Bennabi Meriem, Bengoufa Djaouida, Sundaresh Aparna, Chaabane Arij Ben, Bellivier Frank, Henry Chantal, Kahn Jean-Pierre, Charron Dominique, Krishnamoorthy Rajagopal, Leboyer Marion, Tamouza Ryad

Abstract excerpt

Gene-environment interactions may play an important role in modulating the impact of early-life stressful events on the clinical course of bipolar disorder (BD), particularly associated to early age at onset. Immune dysfunction is thought to be an important mechanism linking childhood trauma with early-onset BD, thus the genetic diversity of immune-related loci may account for an important part of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25790282
DOI: 10.1371/journal.pone.0119702
PMCID: PMC4366110

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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