Association of a common genetic variant of the IGF-1 gene with event-free survival in patients with HER2-positive breast cancer.

doi:10.1007/s00432-012-1355-3

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Article

Association of a common genetic variant of the IGF-1 gene with event-free survival in patients with HER2-positive breast cancer.

Journal of cancer research and clinical oncology - 1 Mar 2013

Muendlein Axel, Lang Alois H, Geller-Rhomberg Simone, Winder Thomas, Gasser Klaus, Drexel Heinz, Decker Thomas, Mueller-Holzner Elisabeth, Chamson Martina, Marth Christian, Hubalek Michael

Abstract excerpt

PURPOSE: Insulin-like growth factor 1 (IGF-1) stimulates mitosis and inhibits apoptosis. High circulating IGF-1 levels are linked with an increased risk of colorectal and breast cancer. Recently, IGF-1 single nucleotide polymorphisms (SNPs), especially variant rs2946834, have been associated with poor clinical outcome in patients with colorectal cancer. In the present study, we aimed to investigate the influence...

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PMID: 23180020
DOI: 10.1007/s00432-012-1355-3

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IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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