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Article

The impact of genetic variants of the IGF-1 axis on surgical outcomes and prognosis in ovarian cancer.

Molecular biology reports - 4 Feb 2026

de Almeida Lopes Inês, Moreira Pires Mariana, Pereira Deolinda, Tavares Valéria, Guerra de Melo Inês, Medeiros Rui

Abstract excerpt

BACKGROUND: Ovarian cancer (OC) remains the most lethal gynaecological malignancy, largely due to late-stage diagnosis, tumour heterogeneity, and high recurrence rates. The insulin-like growth factor-1 (IGF-1) axis has been implicated in tumour proliferation, survival, and treatment resistance. Yet, the prognostic relevance of its genetic variants in OC is not well established. The present study aims to evaluate...

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Source

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Identifiers

PMID: 41636865
DOI: 10.1007/s11033-026-11508-4
PMCID: PMC12872681

Genes

IGF1
IGF1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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