Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen.

The pharmacogenomics journal - 1 Feb 2014

Winder T, Giamas G, Wilson P M, Zhang W, Yang D, Bohanes P, Ning Y, Gerger A, Stebbing J, Lenz H-J

Abstract excerpt

Compelling evidence points to a key role for insulin-like growth factor 1 (IGF1) signaling in breast cancer development and progression. In addition, IGF1 receptor (IGF1R) expression has been correlated and functionally linked with estrogen receptor (ER) signaling. Recent translational studies support a cross talk between IGF1R and ERα at different levels and data suggest enhanced IGF1R signaling as a causative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amplified Fragment Length Polymorphism Analysis
Share to Chemotherapy, Adjuvant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Combined Modality Therapy

Share to Neoplasm Invasiveness

Share to Receptor, IGF Type 1

Share to Receptors, Estrogen

Share to Selective Estrogen Receptor Modulators

Share to Tamoxifen

Source

Identifiers

PMID: 23459444
DOI: 10.1038/tpj.2013.8

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen.PMID 23459444Read ↗

Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01).Semantic proximity Read ↗

Targeting the Insulin-like Growth Factor Receptor: Developing Biomarkers from Gene Expression ProfilingSemantic proximity Read ↗

Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk.Semantic proximity Read ↗

Type 1 IGF receptor in human breast diseasesSemantic proximity Read ↗

Influence of Insulin-Like Growth Factor 1 Gene Expression in Women with Breast Cancer: A Systematic ReviewSemantic proximity Read ↗

Influence of Insulin-Like Growth Factor 1 Gene Expression in Women with Breast Cancer: A Systematic ReviewSemantic proximity Read ↗

Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study.Semantic proximity Read ↗

The Impact of IGF1 Genetic Variants on Surgical Outcomes and Prognosis in Ovarian CancerSemantic proximity Read ↗

Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with the risk of breast cancer in Korean women.Semantic proximity Read ↗

Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.Semantic proximity Read ↗

Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers.Semantic proximity Read ↗

Insulin-Like Growth Factor-I Activates Gene Transcription Programs Strongly Associated With Poor Breast Cancer PrognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.