Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effects of MHC gene dosage and allelic variation on T cell receptor selection.

Cell - 23 Mar 1990

Berg L J, Frank G D, Davis M M

Abstract excerpt

In a T cell receptor transgenic mouse model of thymic selection, the efficiency of selection of the transgenic alpha beta heterodimer is significantly enhanced in animals that express higher densities of the relevant major histocompatibility complex molecule (I-Ek/b). These results imply that there is a stochastic component to positive selection in the thymus. Allelic variants of the original selecting I-Ek...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Gene Expression
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Protein Conformation

Share to Species Specificity

Share to T-Lymphocytes

Source

Identifiers

PMID: 2317862
DOI: 10.1016/0092-8674(90)90352-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

The effects of MHC gene dosage and allelic variation on T cell receptor selection.PMID 2317862Read ↗

The multigenic structure of the MHC locus contributes to positive selection efficiency: a role for MHC class II gene-specific restriction.Semantic proximity Read ↗

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.Semantic proximity Read ↗

The somatically generated T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptorSemantic proximity Read ↗

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic miceSemantic proximity Read ↗

Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development.Semantic proximity Read ↗

The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status.Semantic proximity Read ↗

T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population.Semantic proximity Read ↗

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.Semantic proximity Read ↗

The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo.Semantic proximity Read ↗

MHC class I allele dosage alters CD8 expression by intestinal intraepithelial lymphocytes.Semantic proximity Read ↗

Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.