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Article

The effects of MHC gene dosage and allelic variation on T cell receptor selection.

Cell - 23 Mar 1990

Berg L J, Frank G D, Davis M M

Abstract excerpt

In a T cell receptor transgenic mouse model of thymic selection, the efficiency of selection of the transgenic alpha beta heterodimer is significantly enhanced in animals that express higher densities of the relevant major histocompatibility complex molecule (I-Ek/b). These results imply that there is a stochastic component to positive selection in the thymus. Allelic variants of the original selecting I-Ek...

Topics

Alleles
Animals
CD4 Antigens
Flow Cytometry
Gene Expression
Genetic Variation
Lymphocytes
Major Histocompatibility Complex
Mice
Mice, Transgenic
Polymorphism, Genetic
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell

Species Specificity

T-Lymphocytes

Thymus Gland

Source

Identifiers

PMID: 2317862
DOI: 10.1016/0092-8674(90)90352-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2317862-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The effects of MHC gene dosage and allelic variation on T cell receptor selection.PMID 2317862Read ↗

The multigenic structure of the MHC locus contributes to positive selection efficiency: a role for MHC class II gene-specific restriction.Semantic proximity Read ↗

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.Semantic proximity Read ↗

The somatically generated T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptorSemantic proximity Read ↗

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic miceSemantic proximity Read ↗

Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development.Semantic proximity Read ↗

The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status.Semantic proximity Read ↗

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MHC class I allele dosage alters CD8 expression by intestinal intraepithelial lymphocytes.Semantic proximity Read ↗

Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain.Semantic proximity Read ↗

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