Article
MHC class I allele dosage alters CD8 expression by intestinal intraepithelial lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2001
Podd B S, Aberg C, Kudla K L, Keene L, Tobias E, Camerini V
Abstract excerpt
The development of TCR alphabeta(+), CD8alphabeta(+) intestinal intraepithelial lymphocytes (IEL) is dependent on MHC class I molecules expressed in the thymus, while some CD8alphaalpha(+) IEL may arise independently of MHC class I. We examined the influence of MHC I allele dosage on the development CD8(+) T cells in RAG 2(-/-) mice expressing the H-2D(b)-restricted transgenic TCR specific for the male,...
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