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Article

Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment

2026-07-27

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is driven by persistent HIF-2α transcription program initiated by VHL loss, yet molecular mediators sustaining this program are poorly defined. Using single-cell transcriptomics, we identified lysyl oxidase (LOX) as a driver of ccRCC progression, selectively enriched in a hypoxia/epithelial-mesenchymal transition (EMT) gene program associated with poor outcome. While LOX oxi...

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Identifiers and source

Literature Corpus work
980d8900-ac91-5d3c-8928-71a99a9ba8bd
DOI
10.64898/2026.07.24.739825
Open publication

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Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironmentDOI 10.64898/2026.07.24.739825
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