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Article

Treatment of kidney cancer

28 Apr 2009

Abstract excerpt

Germline inactivation of the VHL tumor suppressor gene is associated with an increased risk of clear cell carcinoma of the kidney in the context of von Hippel-Lindau (VHL) disease. Somatic VHL mutations are also common in nonhereditary (sporadic) clear cell carcinomas. The VHL protein (pVHL) has multiple functions that might be linked to tumor suppression, including targeting the hypoxia inducible factor (HIF)...

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Share to Cancer, Hypoxia, and Metabolism
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Identifiers

PMID: 19402056
DOI: 10.1002/cncr.24232

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