Dominant cataract mutations detected in offspring of gamma-irradiated male mice.

Abstract excerpt

The technique of biomicroscopic eye examination followed by breeding tests provides a new method for detection of dominant mutations in mice. A total of 11 cataract mutations were found among 17,436 offspring of irradiated male mice. No cataract mutations were observed in 8,174 offspring from the control group. All mutations were phenotypically different. Of the 11 cataract mutations, 3 were semilethal in...

Topics

• Animals
• Cataract
• Crosses, Genetic
• Dose-Response Relationship, Radiation
• Gamma Rays
• Genes, Dominant
• Male
• Mice
• Mutation
• Phenotype
• Whole-Body Irradiation