Article
Transgenerational carcinogenesis: induction and transmission of genetic alterations and mechanisms of carcinogenesis.
Mutation research - 1 Nov 2003
Nomura Taisei
Abstract excerpt
Parental exposure, i.e. germ cell exposure to radiation and chemicals, increased the incidence of tumors and malformations in the offspring, and the germ-line alterations that cause cancer are transmissible to further generations. However, tumor incidences were 100-fold higher than those of ordinary mouse mutations and there were apparent strain differences in the types of induced tumors. In human, higher risk of...
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