Article
The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel.
The EMBO journal - 15 Nov 2017
Sabirov Ravshan Z, Merzlyak Petr G, Okada Toshiaki, Islam Md Rafiqul, Uramoto Hiromi, Mori Tomoko, Makino Yumiko, Matsuura Hiroshi, Xie Yu, Okada Yasunobu
Abstract excerpt
The maxi-anion channels (MACs) are expressed in cells from mammals to amphibians with ~60% exhibiting a phenotype called Maxi-Cl. Maxi-Cl serves as the most efficient pathway for regulated fluxes of inorganic and organic anions including ATP However, its molecular entity has long been elusive. By subjecting proteins isolated from bleb membranes rich in Maxi-Cl activity to LC-MS/MS combined with targeted siRNA...
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