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Identification of JadG as the B ring opening oxygenase catalyzing the oxidative C-C bond cleavage reaction in jadomycin biosynthesis.

Chemistry & biology - 21 Nov 2012

Fan Keqiang, Pan Guohui, Peng Xiaojing, Zheng Jianting, Gao Wubin, Wang Juan, Wang Weishan, Li Yue, Yang Keqian

Abstract excerpt

Jadomycin B is a member of atypical angucycline antibiotics whose biosynthesis involves a unique ring opening C-C bond cleavage reaction. Here, we firmly identified JadG as the enzyme responsible for the B ring opening reaction in jadomycin biosynthesis. In vitro analysis of the JadG catalyzed reaction revealed that it requires FMNH(2) or FADH(2) as cofactors in the conversion of dehydrorabelomycin to jadomycin...

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PMID: 23177193
DOI: 10.1016/j.chembiol.2012.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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