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Article

Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens

16 Aug 2017

Abstract excerpt

Adrenergic signaling is known to promote tumor growth and metastasis, but the effects on tumor stroma are not well understood. An unbiased bioinformatics approach analyzing tumor samples from patients with known biobehavioral profiles identified a prominent stromal signature associated with cancer-associated fibroblasts (CAFs) in those with a high biobehavioral risk profile (high Center for Epidemiologic Studies...

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PMID: 28814667
DOI: 10.1172/jci.insight.93076

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