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Article

Nanos maintains germline stem cell self-renewal by preventing differentiation.

Science (New York, N.Y.) - 26 Mar 2004

Wang Zhong, Lin Haifan

Abstract excerpt

Despite much progress in understanding how extrinsic signaling regulates stem cell self-renewal, little is known about how cell-autonomous gene regulation controls this process. In Drosophila ovaries, germline stem cells (GSCs) divide asymmetrically to produce daughter GSCs and cystoblasts, the latter of which develop into germline cysts. Here, we show that removing the translational repressor Nanos from either...

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Identifiers

PMID: 14976263
DOI: 10.1126/science.1093983

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