Article
Correlates of efavirenz exposure in Chilean patients affected with human immunodeficiency virus reveals a novel association with a polymorphism in the constitutive androstane receptor.
Therapeutic drug monitoring - 1 Feb 2013
Cortes Claudia P, Siccardi Marco, Chaikan Ammara, Owen Andrew, Zhang Guijun, la Porte Charles J L
Abstract excerpt
OBJECTIVE: To explore the effect of demographics and single-nucleotide polymorphisms in cytochrome P450 (CYP) 2B6, 2A6, UDP-glucuronosyltransferase (UGT) 2B7, and the constitutive androstane receptor (CAR) genes on efavirenz pharmacokinetics in a Chilean cohort affected with human immunodeficiency virus. METHODS: Timed plasma samples obtained throughout the dosing interval were analyzed for efavirenz...
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