Article
Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients.
The Journal of antimicrobial chemotherapy - 1 Oct 2011
Habtewold Abiy, Amogne Wondwossen, Makonnen Eyasu, Yimer Getnet, Riedel Klaus-Dieter, Ueda Nobuhisa, Worku Alemayehu, Haefeli Walter Emil, Lindquist Lars, Aderaye Getachew, Burhenne Jürgen, Aklillu Eleni
Abstract excerpt
OBJECTIVES: We investigated the long-term effect of efavirenz autoinduction on its plasma/peripheral blood mononuclear cell (PBMC) exposure and the CD4 count, and the importance of sex and pharmacogenetic variations. METHODS: Treatment-naive HIV patients (n = 163) received efavirenz-based antiretroviral therapy. Plasma and intracellular (PBMC) concentrations of efavirenz and 8-hydroxyefavirenz were determined at...
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