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Article

Effects of cytochrome P450 2B6 and constitutive androstane receptor genetic variation on Efavirenz plasma concentrations among HIV patients in Kenya.

PloS one - 1 Jan 2022

Ngayo Musa Otieno, Oluka Margaret, Kwena Zachari Arochi, Bulimo Wallace Dimbuson, Okalebo Faith Apolot

Abstract excerpt

The effects of genetic variation of cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) on efavirenz (EFV) plasma concentration was evaluated among 312 HIV patients in Nairobi Kenya. The EFV plasma concentration at steady-state were determined using ultra-high-performance liquid chromatography with a tandem quadruple mass spectrometer (LC-MS/MS). Thirteen CYP2B6 (329G>T, 341T>C, 444 G>T/C,...

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PMID: 35235559
DOI: 10.1371/journal.pone.0260872
PMCID: PMC8890732

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