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Article

Efavirenz pharmacogenetics in a cohort of Italian patients.

International journal of antimicrobial agents - 1 Feb 2016

Cusato Jessica, Tomasello Cristina, Simiele Marco, Calcagno Andrea, Bonora Stefano, Marinaro Letizia, Leggieri Anna, Allegra Sarah, Di Perri Giovanni, D'Avolio Antonio

Abstract excerpt

The pharmacogenetics and pharmacokinetics of efavirenz (EFV) have been widely studied, although data in the Italian population are limited. Single nucleotide polymorphisms (SNPs) in the CYP2B6 gene have been associated with increased EFV plasma concentrations and central nervous system toxicity. The aim of this work was to evaluate EFV plasma exposure according to SNPs in genes involved in drug metabolism and...

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Source

Identifiers

PMID: 26774523
DOI: 10.1016/j.ijantimicag.2015.11.012

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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