Article
Fidelity of SNP array genotyping using Epstein Barr virus-transformed B-lymphocyte cell lines: implications for genome-wide association studies.
PloS one - 4 Sept 2009
Herbeck Joshua T, Gottlieb Geoffrey S, Wong Kim, Detels Roger, Phair John P, Rinaldo Charles R, Jacobson Lisa P, Margolick Joseph B, Mullins James I
Abstract excerpt
BACKGROUND: As availability of primary cells can be limited for genetic studies of human disease, lymphoblastoid cell lines (LCL) are common sources of genomic DNA. LCL are created in a transformation process that entails in vitro infection of human B-lymphocytes with the Epstein-Barr Virus (EBV). METHODOLOGY/PRINCIPAL FINDINGS: To test for genotypic errors potentially induced by the Epstein-Barr Virus...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.