Article
Identification of structural DNA variations in human cell cultures after long-term passage.
Cell cycle (Georgetown, Tex.) - 1 Jan 2015
Pavlova G V, Vergun A A, Rybalkina E Y, Butovskaya P R, Ryskov A P
Abstract excerpt
Random amplified polymorphic DNA (RAPD) analysis was adapted for genomic identification of cell cultures and evaluation of DNA stability in cells of different origin at different culture passages. DNA stability was observed in cultures after no more than 5 passages. Adipose-derived stromal cells demonstrated increased DNA instability. RAPD fragments from different cell lines after different number of passages...
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