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Using protein microarray technology to screen anti-ERCC1 monoclonal antibodies for specificity and applications in pathology

21 Nov 2012

Abstract excerpt

BACKGROUND: An antibody with cross-reactivity can create unexpected side effects or false diagnostic reports if used for clinical purposes. ERCC1 is being explored as a predictive diagnostic biomarker for cisplatin-based chemotherapy. High ERCC1 expression is linked to drug resistance on cisplatin-based chemotherapy. 8F1 is one of the most commonly used monoclonal antibodies for evaluating ERCC1 expression levels...

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PMID: 23171216
DOI: 10.1186/1472-6750-12-88

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