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Novel humanized monoclonal antibodies against ROR1 for cancer therapy

13 Aug 2024

Abstract excerpt

BACKGROUND: Overexpression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) contributes to cancer cell proliferation, survival and migration, playing crucial roles in tumor development. ROR1 has been proposed as a potential therapeutic target for cancer treatment. This study aimed to develop novel humanized ROR1 monoclonal antibodies and investigate their anti-tumor effects. METHODS: ROR1 expression in...

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PMID: 39138527
DOI: 10.1186/s12943-024-02075-y

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