EGFR protein expression in non-small cell lung cancer predicts response to an EGFR tyrosine kinase inhibitor--a novel antibody for immunohistochemistry or AQUA technology.

doi:10.1158/1078-0432.CCR-11-0209

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Article

EGFR protein expression in non-small cell lung cancer predicts response to an EGFR tyrosine kinase inhibitor--a novel antibody for immunohistochemistry or AQUA technology.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2011

Mascaux Celine, Wynes Murry W, Kato Yasufumi, Tran Cindy, Asuncion Bernadette Reyna, Zhao Jason M, Gustavson Mark, Ranger-Moore Jim, Gaire Fabien, Matsubayashi Jun, Nagao Toshitaka, Yoshida Koichi, Ohira Tatuso, Ikeda Norihiko, Hirsch Fred R

Abstract excerpt

INTRODUCTION: Epidermal growth factor receptor (EGFR) protein expression in non-small cell lung cancer (NSCLC) is not recommended for predicting response to EGFR tyrosine kinase inhibitors (TKI) due to conflicting results, all using antibodies detecting EGFR external domain (ED). We tested the predictive value of EGFR protein expression for response to an EGFR TKI with an antibody that detects the intracellular...

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PMID: 21994417
DOI: 10.1158/1078-0432.CCR-11-0209
PMCID: PMC3266947

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EGFR

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